A, retinol binding protein (RBP) overview
Normal human urine retinol binding protein (RBP) content rarely, about 0.1ug/min. The displacement increase is considered to be a sensitive proximal renal tubule injury index in the diagnosis of. There was a significant positive correlation between RBP and urinary albumin, NAG, B2- micro albumin and so on. In the alkaline environment is more stable than B2-MG, at 37 C temperature does not break down (while the PH5.5 in B2-MG following the rapid decomposition, room temperature for 2 hours after the 80% will be broken down). Urinary RBP as an indicator of renal tubular injury was more sensitive than NAG. In the disease state, urine RBP concentration is 10 times the NAG. Therefore, urinary RBP was more valuable than NAG and B2-MG.
Two, RBP clinical applications
1, the relationship with liver disease: liver disease patients with serum RBP was significantly lower than normal, and the early stage of acute viral hepatitis RBP content decreased significantly compared with the late. The serum RBP level can reflect the changes of liver function accurately and sensitively.
2, the relationship with kidney disease:
RBP stability is good, is a more practical and reliable renal function indicators than beta 2-MG, when the renal tubular dysfunction, urinary RBP can be significantly higher, more accurate and sensitive than creatinine, urea.
3. Relationships with other diseases: level of RBP is reflect nutritional disease curative effect of sensitive, specific indicators and RBP levels in patients with hyperthyroidism than normal low, RBP levels in patients with hypothyroidism higher than normal people. In addition, when the serum RBP lower than normal in half, patients with dark adaptation ability to reduce, suggesting that the serum RBP content can be more sensitive to reflect the lack of vitamin A.